The ultimate NMR research platform

Avance III HD How Bruker provides the fastest, best performing and most flexible NMR research spectrometer on the market

The AVANCE III HD represents the next generation in the very successful AVANCE series product line, which has established Bruker as the global technology and market leader in NMR.

The Avance III HD architecture is based on a forward-thinking electronics concept that delivers an unprecedented level of digital control, fast NMR, high speed spectroscopy, flexibility and exceptionally pure NMR frequency generation. The AVANCE III spectrometer is designed around an advanced digital concept that provides an optimized pathway for highest speed RF generation and data acquisition with a highly modular and scalable transmitter and receiver channel architecture.

  • Patented Direct Digital Synthesis
  • One-chip RF generation
  • High-speed RF generation and data acquisition with minimum event time of 25 ns
  • Scalable transmitters and multiple receiver channels
  • High-dynamic range and digital resolution
  • Large-bandwith digital filtering
  • NMR Thermometer™

The most advanced RF generation in the industry

The AVANCE III features the most advanced RF generation in the industry, a unique digital lock for superb experimental stability, and second-generation digital receiver (2G-DR technology) for high dynamic range, high digital resolution and large bandwidth digital filtering. The result is the extremely fast Avance III spectrometer with 25 ns event timing (12.5 ns clock), including simultaneous phase, frequency and amplitude switching, and unsurpassed RF performance, enabling even the most demanding new solid-state NMR experiments.

Digilock for Experimental stability

The Digilock uses highest speed FPGAs, latest analog-to-digital and digital-to-analog converters with clock rates up to 320 MHz, and provides on-the-fly high speed digital signal processing, hence enabling locking on complex deuterated solvents having multiple solvent peaks. Together with the latest high speed converters and fast digital signal processing this concept provides ultimate performance with higher precision and greater immunity against external RF interferences. Coupled with cold deuterium pre-amplifiers inherent in the design of all Bruker’s CryoProbes, unprecedented lock sensitivity and stability can be achieved. (The DigiLock is a key module of the newly introduced and game-changing CryoProbe™ Prodigy).

SmartVT and the SmartCooler

Further contributing to overall spectrometer stability and NMR probe performance, the SmartVT, a unique, new Variable Temperature (VT) architecture, consist of a modular, plug-and-play multi-channel temperature control system together with the new SmartCooler. The SmartVT controller has been significantly enhanced by incorporating novel airflow monitoring and regulation capabilities, as well as the potential to handle up to four heater channels, while monitoring up to nine thermal sensors, and at a much greater precision and regulation speed than before.

The new SmartCooler, Bruker’s new VT gas pre-conditioning unit to Bruker’s NMR probes, combined with the new SmartVT allows the temperature of the NMR sample is very accurately monitored and controlled, making the NMR results insensitive to laboratory instabilities., e.g. in the VT gas supply of the laboratory and day/night cycles in temperature.

AVANCE III HD consoles

HPLNA for optimal sensitivity and minimum perturbations

The HPLNA is designed for maximum performance for both solid state and liquid state spectroscopy. While latest GaAs technology allows highest sensitivity, the novel 4kW peak power active Transmit/Receive switch provides full linearity in the transmit path of the spectrometer, delivering ultimate selective excitation performance for any NMR application. Due to its well designed packaging and filtering, the HPLNA is virtually immune to electromagnetic interferences and thus avoids any pick-up from unwanted external RF sources. This results in optimal sensitivity while at the same time minimizing the risk of disturbances from digital communication around the NMR laboratory.

  • Digital RF synthesizer SGU3
  • Enhanced Receiver RXAD/2
  • Enhanced HPLNA 1H with 19F
  • HPLNA XBB solids preamplifier
  • Enhanced Tune & Match
  • Preamplifier user interface / Touchscreen
  • Nanobay ‘CryoProbe ready’
  • Support of NMR Thermometer