AVANCE NEO The Definitive NMR Research Platform

The AVANCE NEO represents the next generation in the very successful AVANCE series product line, which has established Bruker as the global technology and market leader in NMR.

While its predecessor, the AVANCE III HD architecture, already provided cutting-edge NMR performance, the AVANCE NEO takes this a step further. It features even faster control, improved dynamic range and greater flexibility and scalability.

The AVANCE NEO is based on a ‘transceive’ principle, meaning each NMR channel has both transmit and receive capabilities. So each channel is its own independent spectrometer with the full RF generation, transmission and receive infrastructure. This architecture provides the greatest flexibility in terms of instrument configuration and multi-channel operation. Multi-receive experiments are easily implemented with this new approach.

Also new in the AVANCE NEO is the concept of an embedded acquisition server and an associated client-server software architecture (TopSpin 4 and higher). This leaves the spectrometer independent of the client computer, thus giving the user the opportunity to control the system via operating system and location of choice (as in principle one could control the system via the cloud).

With the frequency range now extended to beyond 1.2 GHz, and with various functional enhancements in setup, diagnostics, memory buffers etc, the AVANCE NEO is well positioned to serve as the research platform of choice for the current and the next generation of NMR spectroscopists.

AVANCE NEO The Definitive NMR Research Platform

Taking Rf Generation and detection one step further

With the AVANCE NEO the most advanced RF generation and a new generation digital receiver are combined in an unique transceiver technology. Each channel is equipped with four independent NCO’s ( numerically controlled oscillators) and one receiver. Frequency, amplitude and phase can be simultaneously set in 12.5 nanoseconds. Each transceiver features 1 Gigabytes of Waveform memory allowing the most complex shapes and sequences to be executed.

The receiver operates with a 1.852 GHz intermediate frequency, allowing spectrometer frequencies above 1.25 GHz. The analog digital converter provides the acquisition of digitally filtered spectra with up 7.5 MHz sweep width. FID’s are accumulated into double precision data eliminating any possibility of data overflow.

Introducing wide-band Rf amplifiers

The AVANCE NEO is equipped with novel wide-band amplifiers, thus eliminating the need for separate high-band and low-band amplifiers. These amplifiers are standard for liquids applications and will provide full coverage of all frequencies with over 100W in the high frequency range and over 500W in the range of heteronuclei. Higher power amplifier are used in instruments equipped for solid-state NMR or imaging applications.

HPLNA for optimal sensitivity and minimum perturbations

The HPLNA is designed for maximum performance for both solid-state and liquid state spectroscopy. While the latest GaAs technology allows the highest sensitivity, the novel 4kW peak power active Transmit/Receive switch provides full linearity in the transmit path of the spectrometer, delivering ultimate selective excitation performance for any NMR application. In combination with the new AVANCE NEO electronics it is now possible to display a complex tuning and matching curve.

Due to its well designed packaging and filtering, the HPLNA is virtually immune to electromagnetic interferences and thus avoids any pick-up from unwanted external RF sources, such as HDTV. This results in optimal sensitivity while at the same time minimizing the risk of disturbances from digital communication around the NMR laboratory.


The Digilock uses highest speed FPGAs, the latest analog-to-digital and digital-to-analog converters with clock rates up to 320 MHz, and provides on-the-fly high speed digital signal processing, hence enabling locking on complex deuterated solvents having multiple solvent peaks. Together with the latest high speed converters and fast digital signal processing this concept provides ultimate performance with higher precision and greater immunity against external RF interferences. Coupled with cold deuterium pre-amplifiers inherent in the design of all Bruker’s CryoProbes, unprecedented lock sensitivity and stability can be achieved.

SmartVT and the SmartCooler

Further contributing to overall spectrometer stability and NMR probe performance, the SmartVT, a unique, new Variable Temperature (VT) architecture, consists of a modular, plug-and-play multi-channel temperature control system together with the new SmartCooler. The SmartVT controller has been significantly enhanced by incorporating novel airflow monitoring and regulation capabilities, as well as the potential to handle up to four heater channels, while monitoring up to nine thermal sensors, and at a much greater precision and regulation speed than before.

The new SmartCooler, Bruker’s new VT gas pre-conditioning unit for Bruker’s NMR probes, combined with the new SmartVT, allows the temperature of the NMR sample to be very accurately monitored and controlled, making the NMR results insensitive to laboratory instabilities., e.g. in the VT gas supply of the laboratory and daily cycles in temperature.

The direct communication between lock and variable temperature controller enables features such as the NMR Thermometer and safety features such as temperature limitations based on the selected solvent.