The key to performance and reliability for nano flow MS

The Bruker CaptiveSpray principle: Stable and roubust nanoflow LC/MS is still a challenge in proteomics analysis. The Bruker CaptiveSpray source is a revolutionary ion source with a patented design that provides easy operation just as simple as the normalflow exectrospray.

CaptiveSpray delivers nanospray sensitivity, resists plugging, and provides reproducible, uninterrupted flow for even the most complex proteomics samples.


The CaptiveSpray source mounts directly onto all current Bruker API mass spectrometers. The Ion Transfer Interface connects directly to the front of the capillary, eliminating the need for complex XYZ adjustable stages.

Bruker's revolutionary CaptiveSpray source is now available with a smart dopant addition option—the nanoBooster

CaptiveSpray nanoBooster brings your MS to the next performance level and provides even higher flexibility.

  • Boosts nanoflow sensitivity
  • Pushes up ID rates
  • Enables Glycoanalysis
  • Supercharges capability

Ease of Use

CaptiveSpray provides a vortex gas that sweeps around the emitter spray tip to desolvate and focus the Taylor cone into the MS inlet capillary. The vacuum seal to the MS ion guide draws all of the sample ions into the MS increasing the efficiency of sample transfer from the spray tip into the mass spectrometer. The direct connection to the inlet capillary eliminates the need for any source adjustment making the CaptiveSpray source truly Plug-and-Play.

Smart Ionization Support by Dopant-enriched Gas Supply

The nanoBooster option allows the modification and vapor enrichment of gas that flows around the emitter. Dependent on the used dopant, either charge stripping or chare enhancement of peptides and proteins can be achieved during the ionization process. Charge enhancement is advantageous for the analysis of large biomolecules due to the reduction of the mass-to-charge (m/z) ratio. Furthermore, higher charge stages increase efficiency of electron transfer dissociation (ETD) MS/MS.