fast and comprehensive LC-MSn screening for drugs and drugs of abuse

Toxtyper™ delivers a robust and automated drug screening solution based on the latest LC-MSn ion trap technology, the amaZon speed. The Toxtyper provides a combination of the highest performance LC-MS/MS and easy-to-use screening with the greatest transferability of results from lab to lab.

The Toxtyper solution was developed to meet the needs of clinical and routine labs. The unique patented SmartFrag™ technology removes variation and the need for tuning from the MS/MS process. Data acquisition and post-processing is completely hidden by Compass OpenAccess, which provides a wizard for easy web-based access.

  • Unique and comprehensive library of over 830 compounds based on retention time, MS, MS2 and MS3 ion trap spectra
  • Full UHPLC-MSn screening method
  • Fast results within 11 min duty cycle
  • Ease-of-use by Compass OpenAccess sample management and fully automated reporting

"For research use only. Not for use in diagnostic procedures!"

Toxtyper: the solution for LC toxicology screening

The high demand in clinical and forensic toxicology for comprehensive, specific and transferable techniques has led to new developments in the field of Liquid chromatography-tandem mass spectrometry (LC-MS). LC-MS combined with library searching is one of the most promising screening solutions for modern toxicology. The Toxtyper solution is using state-of-the-art ultra high performance liquid chromatography (UHPLC) combined with true MSn and a comprehensive drug library.

Library of Drugs and Drugs of Abuse (DOA)

The Toxtyper holds a high quality spectral library of more than 830 compounds of clinical and forensic interest with over 2600 spectra of MS, MS2 and MS3 experiments. A novel library search module as part of Brukers’ proven Compass software package allows for unambiguous and fast (11 min duty cycle) drug identification.

Sample preparation for a wide range of analytes

Different well established sample preparation methods such as liquid-liquid extraction (LLE) as well as solid-phase extraction (SPE ) can be used for the Toxtyper workflow and are well-suited for the extraction of a wide range of analytes such as hypnotics, neuroleptics, antidepressants and many others.

Transferability by SmartFrag™

The Toxtyper solution is setting new standards in LC-MS/MS toxicology screening and transferability from lab-to-lab. Brukers patented SmartFrag technology virtually removes variation and tuning from the MS/MS process. Furthermore, results and libraries are easily transferable from lab-to-lab and experiment-to-experiment.

Easy-to use - developed for the routine lab

Current toxicology workflows, LC-MS/MS software and instruments often require expert MS knowledge, which is not always available in routine laboratories. The Toxtyper solution was developed with this in mind and provides several features to meet the needs of clinical and routine labs. The user is guided through the complete workflow by an easy web-based access.

An automated ID reporting enables fast inspection of results and automatic sending of reports by email to senior laboratory personnel.